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Wulff labs kca3.1 channel
Kca3.1 Channel, supplied by Wulff labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kca3%2E1+channels/kca3+1+channel/pm36622407-182-0-21
Average 90 stars, based on 1 article reviews
kca3.1 channel - by Bioz Stars, 2026-10
90/100 stars

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Related Articles

Activation Assay:

Article Title: Human T cells in silico: Modelling their electrophysiological behaviour in health and disease.
Article Snippet: Although various types of ion channels are known to have an impact on human T cell effector functions, their exact mechanisms of influence are still poorly understood.. The 1 These authors contributed equally to this work.. 2 patch clamp technique is a well-established method for the investigation of ion channels in neurons and T cells.

Article Title: The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca 2+ -activated K Ca 3.1 channels.
Article Snippet: Cocozza Germana (Orcid ID: 0000-0001-7005-7983) Wulff Heike (Orcid ID: 0000-0003-4437-5763) The feeding behaviour of ALS mouse models is modulated by the Ca2+-activated KCa3.1 channels Running: The Role of microglial KCa3.1 in ALS Authors: Germana Cocozza,1 Stefano Garofalo,2 Marta Morotti,2 Giuseppina Chece,2 Alfonso Grimaldi,3 Mario Lecce,4 Ferdinando Scavizzi,5 Rossella Menghini6, Viviana Casagrande6, Massimo Federici6, Marcello Raspa,5 Heike Wulff,7 Cristina Limatola1,8 Affiliations: 1IRCCS Neuromed, Pozzilli, Italy.

Article Title: Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models.
Article Snippet: Blockade of KCa3.1 channels has been suggested as a novel strategy to reduce microglia activation.. The concept has been confirmed by neuroprotective effects in a rat brain ischemia-reperfusion model and reduced microglia activation surrounding glioblastomas.. Cumulating evidence exists that microglia activation significantly contributes to epileptogenesis as well as intrinsic severity in the chronic epileptic brain.

Article Title: Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology.
Article Snippet: A network of ion currents influences basic cellular T cell functions.. After T cell receptor activation, changes in highly regulated calcium levels play a central role in triggering effector functions and cell differentiation.. A dysregulation of these processes might be involved in the pathogenesis of several diseases.

Article Title: Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases
Article Snippet: The lower sensitivity of PBMCs might be explained by a rapid up-regulation of KCa3.1 channels in naive and T CM cells upon stimulation as has been reported previously ( Ghanshani et al., 2000 ; Wulff et al., 2003 ).

Article Title: Activity-Dependent Facilitation of Ca V 1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons
Article Snippet: The identity of potassium current as KCa3.1 was confirmed by a block by 1 μ m TRAM-34, a selective blocker of KCa3.1 channels ( D ; Wulff et al., 2000 , 2007 ).

Article Title: Targeting K ca 3.1 Channels in Cancer.
Article Snippet: 45 D’Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, Grimaldi A, Lauro C, Cantore G, Santoro A, Fioretti B, Franciolini F, Wulff H, Limatola C: Kca3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.

Article Title: KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
Article Snippet: KCa3.1 channels regulate calcium entry into cells through modulating calcium-signaling processes, which is necessary for maintaining various cellular activation processes such as proliferation, migration, and cytokine production (Cruse et al., 2006; Wulff and Castle, 2010; Chen et al., 2011).

Migration:

Article Title: Human T cells in silico: Modelling their electrophysiological behaviour in health and disease.
Article Snippet: Although various types of ion channels are known to have an impact on human T cell effector functions, their exact mechanisms of influence are still poorly understood.. The 1 These authors contributed equally to this work.. 2 patch clamp technique is a well-established method for the investigation of ion channels in neurons and T cells.

Article Title: The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca 2+ -activated K Ca 3.1 channels.
Article Snippet: Cocozza Germana (Orcid ID: 0000-0001-7005-7983) Wulff Heike (Orcid ID: 0000-0003-4437-5763) The feeding behaviour of ALS mouse models is modulated by the Ca2+-activated KCa3.1 channels Running: The Role of microglial KCa3.1 in ALS Authors: Germana Cocozza,1 Stefano Garofalo,2 Marta Morotti,2 Giuseppina Chece,2 Alfonso Grimaldi,3 Mario Lecce,4 Ferdinando Scavizzi,5 Rossella Menghini6, Viviana Casagrande6, Massimo Federici6, Marcello Raspa,5 Heike Wulff,7 Cristina Limatola1,8 Affiliations: 1IRCCS Neuromed, Pozzilli, Italy.

Article Title: Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models.
Article Snippet: Blockade of KCa3.1 channels has been suggested as a novel strategy to reduce microglia activation.. The concept has been confirmed by neuroprotective effects in a rat brain ischemia-reperfusion model and reduced microglia activation surrounding glioblastomas.. Cumulating evidence exists that microglia activation significantly contributes to epileptogenesis as well as intrinsic severity in the chronic epileptic brain.

Article Title: Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology.
Article Snippet: A network of ion currents influences basic cellular T cell functions.. After T cell receptor activation, changes in highly regulated calcium levels play a central role in triggering effector functions and cell differentiation.. A dysregulation of these processes might be involved in the pathogenesis of several diseases.

Article Title: Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases
Article Snippet: The lower sensitivity of PBMCs might be explained by a rapid up-regulation of KCa3.1 channels in naive and T CM cells upon stimulation as has been reported previously ( Ghanshani et al., 2000 ; Wulff et al., 2003 ).

Article Title: Activity-Dependent Facilitation of Ca V 1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons
Article Snippet: The identity of potassium current as KCa3.1 was confirmed by a block by 1 μ m TRAM-34, a selective blocker of KCa3.1 channels ( D ; Wulff et al., 2000 , 2007 ).

Article Title: Targeting K ca 3.1 Channels in Cancer.
Article Snippet: 45 D’Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, Grimaldi A, Lauro C, Cantore G, Santoro A, Fioretti B, Franciolini F, Wulff H, Limatola C: Kca3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.

Article Title: KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
Article Snippet: KCa3.1 channels regulate calcium entry into cells through modulating calcium-signaling processes, which is necessary for maintaining various cellular activation processes such as proliferation, migration, and cytokine production (Cruse et al., 2006; Wulff and Castle, 2010; Chen et al., 2011).

Functional Assay:

Article Title: Human T cells in silico: Modelling their electrophysiological behaviour in health and disease.
Article Snippet: Although various types of ion channels are known to have an impact on human T cell effector functions, their exact mechanisms of influence are still poorly understood.. The 1 These authors contributed equally to this work.. 2 patch clamp technique is a well-established method for the investigation of ion channels in neurons and T cells.

Article Title: The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca 2+ -activated K Ca 3.1 channels.
Article Snippet: Cocozza Germana (Orcid ID: 0000-0001-7005-7983) Wulff Heike (Orcid ID: 0000-0003-4437-5763) The feeding behaviour of ALS mouse models is modulated by the Ca2+-activated KCa3.1 channels Running: The Role of microglial KCa3.1 in ALS Authors: Germana Cocozza,1 Stefano Garofalo,2 Marta Morotti,2 Giuseppina Chece,2 Alfonso Grimaldi,3 Mario Lecce,4 Ferdinando Scavizzi,5 Rossella Menghini6, Viviana Casagrande6, Massimo Federici6, Marcello Raspa,5 Heike Wulff,7 Cristina Limatola1,8 Affiliations: 1IRCCS Neuromed, Pozzilli, Italy.

Article Title: Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models.
Article Snippet: Blockade of KCa3.1 channels has been suggested as a novel strategy to reduce microglia activation.. The concept has been confirmed by neuroprotective effects in a rat brain ischemia-reperfusion model and reduced microglia activation surrounding glioblastomas.. Cumulating evidence exists that microglia activation significantly contributes to epileptogenesis as well as intrinsic severity in the chronic epileptic brain.

Article Title: Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology.
Article Snippet: A network of ion currents influences basic cellular T cell functions.. After T cell receptor activation, changes in highly regulated calcium levels play a central role in triggering effector functions and cell differentiation.. A dysregulation of these processes might be involved in the pathogenesis of several diseases.

Article Title: Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases
Article Snippet: The lower sensitivity of PBMCs might be explained by a rapid up-regulation of KCa3.1 channels in naive and T CM cells upon stimulation as has been reported previously ( Ghanshani et al., 2000 ; Wulff et al., 2003 ).

Article Title: Activity-Dependent Facilitation of Ca V 1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons
Article Snippet: The identity of potassium current as KCa3.1 was confirmed by a block by 1 μ m TRAM-34, a selective blocker of KCa3.1 channels ( D ; Wulff et al., 2000 , 2007 ).

Article Title: Targeting K ca 3.1 Channels in Cancer.
Article Snippet: 45 D’Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, Grimaldi A, Lauro C, Cantore G, Santoro A, Fioretti B, Franciolini F, Wulff H, Limatola C: Kca3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.

Article Title: KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
Article Snippet: KCa3.1 channels regulate calcium entry into cells through modulating calcium-signaling processes, which is necessary for maintaining various cellular activation processes such as proliferation, migration, and cytokine production (Cruse et al., 2006; Wulff and Castle, 2010; Chen et al., 2011).

Expressing:

Article Title: Human T cells in silico: Modelling their electrophysiological behaviour in health and disease.
Article Snippet: Although various types of ion channels are known to have an impact on human T cell effector functions, their exact mechanisms of influence are still poorly understood.. The 1 These authors contributed equally to this work.. 2 patch clamp technique is a well-established method for the investigation of ion channels in neurons and T cells.

Article Title: The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca 2+ -activated K Ca 3.1 channels.
Article Snippet: Cocozza Germana (Orcid ID: 0000-0001-7005-7983) Wulff Heike (Orcid ID: 0000-0003-4437-5763) The feeding behaviour of ALS mouse models is modulated by the Ca2+-activated KCa3.1 channels Running: The Role of microglial KCa3.1 in ALS Authors: Germana Cocozza,1 Stefano Garofalo,2 Marta Morotti,2 Giuseppina Chece,2 Alfonso Grimaldi,3 Mario Lecce,4 Ferdinando Scavizzi,5 Rossella Menghini6, Viviana Casagrande6, Massimo Federici6, Marcello Raspa,5 Heike Wulff,7 Cristina Limatola1,8 Affiliations: 1IRCCS Neuromed, Pozzilli, Italy.

Article Title: Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models.
Article Snippet: Blockade of KCa3.1 channels has been suggested as a novel strategy to reduce microglia activation.. The concept has been confirmed by neuroprotective effects in a rat brain ischemia-reperfusion model and reduced microglia activation surrounding glioblastomas.. Cumulating evidence exists that microglia activation significantly contributes to epileptogenesis as well as intrinsic severity in the chronic epileptic brain.

Article Title: Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology.
Article Snippet: A network of ion currents influences basic cellular T cell functions.. After T cell receptor activation, changes in highly regulated calcium levels play a central role in triggering effector functions and cell differentiation.. A dysregulation of these processes might be involved in the pathogenesis of several diseases.

Article Title: Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases
Article Snippet: The lower sensitivity of PBMCs might be explained by a rapid up-regulation of KCa3.1 channels in naive and T CM cells upon stimulation as has been reported previously ( Ghanshani et al., 2000 ; Wulff et al., 2003 ).

Article Title: Activity-Dependent Facilitation of Ca V 1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons
Article Snippet: The identity of potassium current as KCa3.1 was confirmed by a block by 1 μ m TRAM-34, a selective blocker of KCa3.1 channels ( D ; Wulff et al., 2000 , 2007 ).

Article Title: Targeting K ca 3.1 Channels in Cancer.
Article Snippet: 45 D’Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, Grimaldi A, Lauro C, Cantore G, Santoro A, Fioretti B, Franciolini F, Wulff H, Limatola C: Kca3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.

Article Title: KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.
Article Snippet: KCa3.1 channels regulate calcium entry into cells through modulating calcium-signaling processes, which is necessary for maintaining various cellular activation processes such as proliferation, migration, and cytokine production (Cruse et al., 2006; Wulff and Castle, 2010; Chen et al., 2011).



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